منابع مشابه
Analytical cell adhesion chromatography reveals impaired persistence of metastatic cell rolling adhesion to P-selectin.
Selectins facilitate the recruitment of circulating cells from the bloodstream by mediating rolling adhesion, which initiates the cell-cell signaling that directs extravasation into surrounding tissues. To measure the relative efficiency of cell adhesion in shear flow for in vitro drug screening, we designed and implemented a microfluidic-based analytical cell adhesion chromatography system. Th...
متن کاملThe state diagram for cell adhesion under flow: leukocyte rolling and firm adhesion.
Leukocyte adhesion under flow in the microvasculature is mediated by binding between cell surface receptors and complementary ligands expressed on the surface of the endothelium. Leukocytes adhere to endothelium in a two-step mechanism: rolling (primarily mediated by selectins) followed by firm adhesion (primarily mediated by integrins). Using a computational method called "Adhesive Dynamics," ...
متن کاملBiomechanics of cell rolling: shear flow, cell-surface adhesion, and cell deformability.
The mechanics of leukocyte (white blood cell; WBC) deformation and adhesion to endothelial cells (EC) has been investigated using a novel in vitro side-view flow assay. HL-60 cell rolling adhesion to surface-immobilized P-selectin was used to model the WBC-EC adhesion process. Changes in flow shear stress, cell deformability, or substrate ligand strength resulted in significant changes in the c...
متن کاملWeak rolling adhesion enhances bacterial surface colonization.
Bacterial adhesion to and subsequent colonization of surfaces are the first steps toward forming biofilms, which are a major concern for implanted medical devices and in many diseases. It has generally been assumed that strong irreversible adhesion is a necessary step for biofilm formation. However, some bacteria, such as Escherichia coli when binding to mannosylated surfaces via the adhesive p...
متن کاملRolling Friction and Adhesion between Smooth Solids
Rolling friction has been explained in terms of crack propagation through an adhesive joint. The contact between a smooth cylinder and flat has been regarded as an adhesive junction bounded by two cracks moving in the same direction at the same speed, one crack continually opening and one closing. Propagation of these cracks requires a force which is calculated from crack theory and shown to be...
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ژورنال
عنوان ژورنال: Annual Review of Cell and Developmental Biology
سال: 2010
ISSN: 1081-0706,1530-8995
DOI: 10.1146/annurev.cellbio.042308.113238